Untargeted metabolomics of bladder tissue using liquid chromatography‑ultrahigh‑resolution mass spectrometry for cancer biomarker detection

March 2024

Authors: MD, PhD, FEBU Krzysztof Ossoliński, MD, PhD, FEBU Tadeusz Ossolinski, MD, FEBU Anna Ossolińska, Joanna Nizioł a, Aneta Płaza-Altamer a, Artur Kołodziej a, Zuzanna Krupa c, Tomasz Ruman a

Abstract

This study represents the first application of untargeted UHPLC‑UHRMS metabolomic analysis to human bladder tissue, comparing tumor tissue with adjacent normal tissue samples. The aim was to uncover tissue-level metabolic biomarkers for bladder cancer. Multivariate statistical analysis distinguished metabolites between cancerous and normal tissues, identifying a panel of tissue biomarkers with high discriminatory power. This approach demonstrates promise for spatial metabolomics in tumor identification and staging

Full link below:

Untargeted metabolomics of bladder tissue using liquid chromatography and quadrupole time-of-flight mass spectrometry for cancer biomarker detection – ScienceDirect